Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia

David R Witty,Giuseppe Alvaro,Dominique Derjean,Gerard M. P. Giblin,Kevin Gunn,Charles H. Large,David T. MacPherson,Valerie Morisset,Davina Owen,Joanne Palmer,François Rugiero,Simon Tate,Christopher A Hinkley,Himanshu Naik

Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia

2020

David R Witty
Giuseppe Alvaro
Dominique Derjean
Gerard M. P. Giblin
Kevin Gunn
Charles H. Large
David T. MacPherson
Valerie Morisset
Davina Owen
Joanne Palmer
François Rugiero
Simon Tate
Christopher A Hinkley
Himanshu Naik

Drugs that block voltage-gated sodium channels (NaVs) have utility in treating conditions including pain, epilepsy, and cardiac arrhythmias and as anesthetics ( Lancet Neurol.20109413424; Expert Op...

Keywords:

Trigeminal neuralgia
Sodium channel blocker
Pharmacology
Biology
use dependent

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