Research of the relationship between thyroid autoantibodies and thyroid cancer

Objective Retrospectively evaluation the relationship between thyroid cancer and serologic thyroid autoantibodies thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb).Methods We retrospectively reviewed 283 patients of differentiation thyroid cancer from Jan 2001 to Dec 2009,and 500 nodular goiter patients were taken as control.Results On the multivariate analysis,decreased tumor size,elevation of TgAb and TSH were all significant independent factors for thyroid cancer.the occurrence of elevation of TgAb was significant higher in thyroid cancer patients with lymph node metastasis than those without (P ＜ 0.05).Conclusion A positive serum TgAb test was an independent predictor for thyroid cancer and may be connected with lymph node metastasis. Key words: Thyroid cancer;  Thyroid peroxidase antibody (TPOAb) ;  Thyroglobulin antibody(TGAb) ;  TSH(thyrotropin)