An unusual case of retinopathy of prematurity
2007
Aims: Stage 3 retinopathy of prematurity (ROP) usually develops in the very small babies. An infant born at 30 (2) weeks' gestation and of birth weight 2102 g was found to have stage 3 ROP bilaterally. The unusual severity of the disease in a child of birth weight > 2000 g prompted further investigation. The aim was to look for any genetic causes for ROP. Methods: Chromosomal analysis followed by vasculoendothelial growth factor (VEGF) analysis. Results: Unbalanced translocation 18p (monosomy) and 6p (trisomy). Overexpression of VEGF. Conclusions: Overexpression of VEGF contributed to the unusual severity of ROP in this relatively large baby.
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