COMPARISON OF IODINATED CONTRAST MEDIA-INDUCED RENAL VASOCONSTRICTION IN HUMAN, RABBIT, DOG, AND PIG ARTERIES

RATIONALE AND OBJECTIVESContrast media (CM)-induced renal vasoconstriction is an important factor in the pathogenesis of CM-induced nephrotoxicity. The effects of ionic, high-osmolar CM sodium/meglumine diatrizoate and nonionic, low-osmolar CM iohexol and iopamidol were studied in rabbit, dog, and p