Efficient synthesis of new oxindol-based heterocyclic entities via indolin-2-one derivatives

2014 
Abstract New series of oxindol-based heterocyclic entities ( 2 – 11 ) have been designed and synthesized using indolin-2-one derivatives as key materials ( 1a – d ). The chemical structures of the new synthesized compounds were characterized by FTIR, 1 HNMR, 13 CNMR, MS spectroscopy and elemental analyses. Three of the newly synthesized compounds were tested for anticancer activity in the National Cancer Institute (NCI) against human panel breast cancer cell line MCF7 , from the in vitro assays compound 6c presented promising anti-cancer activity using Doxorubicin as a reference. Compound 6c could be a lead compound for discovery of new anticancer agent.
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