Estudo multicêntrico comparativo entre efeitos do benazepril e captopril na hipertensäo arterial sistêmica leve e moderada

PURPOSE--To evaluate the efficacy and safety of benazepril versus captopril in patients with mild or moderate systemic arterial hypertension (SAH). METHODS--A multicenter, double-blind, randomized trial analyzed 174 patients, mean age of 52 +/- 9 years, 68 (39 per cent ) men. After 2 weeks under placebo, 90 patients were treated, during 6 weeks, with 10 mg, once a day, of benazepril (BZ) and 50 mg, twice a day, of captopril (CPT). At week 3, 25 mg of hydrochlorothiazide (HCT) was added if diastolic blood pressure (DBP) was greater than 90 mmHg. Side effects were analyzed as a not related, unlikely, possible, probable and definitive regard to treatment. RESULTS--Systolic (p 90 mmHg at week 3. Heart rate was unchanged. The response to treatment was better at BZ group (74 per cent versus 59 per cent of good and excellent response; p = 0.037). Side effects classified as probable or definitive in relation to the treatment occur in 3 (3 per cent ) and 10 (11 per cent ), respectively at BZ an CPT groups. Laboratorial changes were not observed during treatment. CONCLUSION--BZ (10 mg) was superior to CPT (50 mg) in patients with discrete and moderate SAH (Au)