AGGRESSIVE WEIGHT LOSS PROGRAM WITH A KETOGENIC INDUCTION PHASE FOR THE TREATMENT OF CHRONIC PLAQUE PSORIASIS

Chronic plaque psoriasis is an inflammatory skin disease associated with obesity,characterized by low-grade inflammation. Weight loss (WL) has been demonstrated to reduce psoriasis severity and inflammation. Very low-calorie ketogenic diet (VLCKD) has been associated with a significant reduction in visceral adipose tissue and keton bodies likely have anti-inflammatory proprieties. We evaluate the efficacy of an aggressive WL program with a ketogenic induction phase as first-line treatment of chronic plaque psoriasis. We conducted a single-arm trial conducted (NCT03531528). Adult overweight/obese patients (N=37)with stable chronic plaque psoriasis underwent a 10-week two-phase WL program consisting in a 4-week protein-sparing, VLCKD ( With a mean body weight reduction of 12.0%,dietary intervention resulted in a significant reduction in PASI: mean change, -10.6 [95%CI, -12.8 to -8.4] (P In adult overweight patients with stable chronic plaque psoriasis an aggressive dietary WL program consisting in a ketogenic regimen followed by a balanced, hypocaloric Mediterranean-like diet appeared an efficacious first-line strategy for improving disease severity. Comparative studies with other dietary regimens and long-term efficacy data are warranted.