Characterization of the sensitivity to various genotoxic agents of the UVU1 CHO cell line, a double mutant from UV complementation group 1

Abstract The UVU1 CHO cell line, a double mutant of the excision repair complementation group 1 UV4 cell line was characterized by a higher UV sensitivity than its parent (Busch et al (1989) Mutagenesis 4, 349–354). We show here that this mutant is not affected in a UV mutagenic pathway. In addition, the UVU1 cell line is about two-fold more sensitive to N -methyl- N ′-nitro- N -nitrosoguanidine treatment than its parent without being more sensitive to cross-linking agents or ionizing radiations.