Small-molecule-based Human Genome G4 Profiling Reveals Potential Gene Regulation Activity

Small-molecule-based G4 isolation from genomic DNA has enabled the identification of a total of 51 446 PQSs (potential G-quadruplex sites). Incubating cells with PDP for 3 h to 72 h resulted in the differential expression of a variety of genes, indicating a potential function of G4s in gene regulation.