CMOS BQJ detector chip with integrated charge-amplifiers for fluorescence measurements

Abstract A CMOS buried quad-junction (BQJ) photodetector chip was designed for quantitative analysis in multi-labeling fluorescence detection applications. The chip integrates four-channel charge preamplifiers associated to the multi-output BQJ detector. The chip was tested for noise analysis and evaluation of the amplifiers’ characteristics. It has a sensitivity of 21.2 V/lx s at 555 nm and a detectivity D * up to 3 × 10 13  cm Hz 1/2  W −1 . A test of the chip for a two-label fluorescence case was performed using a mixture of quantum dots in a priori unknown proportions. Good agreement was obtained between the modeled and measured results.