Mesenchymal Stem Cells in the Treatment of Type 1 DiabetesMellitus
2015
Diabetes mellitus type 1 is a form of diabetes mellitus that
results from the autoimmune destruction of insulin-producing
beta cells in the pancreas. The current gold standard therapy
for pancreas transplantation has limitations because of the
long list of waiting patients and the limited supply of donor
pancreas. Mesenchymal stem cells (MSCs), a relatively new
potential therapy in various fields, have already made their
mark in the young field of regenerative medicine. Recent
studies have shown that the implantation of MSCs decreases
glucose levels through paracrine influences rather than through
direct transdifferentiation into insulin-producing cells.
Therefore, these cells may use pro-angiogenic and
immunomodulatory effects to control diabetes following the
cotransplantation with pancreatic islets. In this review, we
present and discuss new approaches of using MSCs in the
treatment of diabetes mellitus type 1.
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