Synthesis of enantiopure 3-hydroxymethylchromanes via intramolecular nitrone cycloaddition

Abstract Enantiopure ( R ) and ( S ) 3-hydroxymethylchromanes were prepared by the intramolecular nitrone cycloaddition strategy, starting from allyl-type ethers of 2-hydroxybenzaldehydes and using ( R )- N -( α -phenylethyl)hydroxylamine as chiral auxiliary.