Acroquinolones A and B, two polyphenolic isoprenylated acetophenone-quinolone hybrids with anti-proliferative activities from Acronychia pedunculata (L.) Miq.

Two new compounds belonging to a new class of acetophenone-alkaloid hybrids, acroquinolones A (1a) and B (1b), together with six known compounds, were isolated from the leaves of Acronychia pedunculata (L.) Miq. Their structures contain a quinolone and an acetophenone fragment, connected through an isopentyl unit. Attempts to isolate more hybrids from another sample collected at the same location but during a different season led to the isolation of a new tocopherol (2). The new compounds were evaluated against several cancer cell lines.