STUDIES ON THE CELLULAR-IMMUNITY ACCORDING TO THE GRADE OF HISTOLOGICAL DEPTH OF INVASION IN GASTRIC CARCINOMA

We investigated cellular immunity and the sate of metastasis to lymph nodes according to the depth of invasion in gastric carcinoma.Skin tests (PHA, Su-PS, PPD), blastoformation (PHA, PWM) and T cell subsets (OKT 3, 4, 8, 4/8, Leu 11, 7) in peripheral blood and regional lymph nodes were evaluated.In patients with carcinoma invading from the mucosa to the submucosa, skin tests, the number of T cell subsets, and blastformation were not depressed in peripheral blood and lymph nodes.However cellular immunity was decreased and the rate of metastasis to lymph nodes was increased according to the invasion of carcinoma.