A novel BCR-ABL fusion transcript (e15a2) in 2 patients with atypical chronic myeloproliferative syndrome.

The BCR-ABL chimeric gene results from a reciprocal translocation, t(9;22)(q34;q11). The breakpoint on chromosome 9 is in the majority of cases 5′ to ABL exon 2, whereas the breakpoints on chromosome 22 can occur in various regions within the BCR gene, giving rise to different BCR-ABL junction