CMR detects abnormal septal convexity into the left ventricle in preclinical hypertrophic cardiomyopathy

Background Sarcomeric gene mutations are responsible for hypertrophic cardiomyopathy (HCM). In gene mutation carriers without significant left ventricular (LV) hypertrophy (G +LVH-), subtle abnormalities can exist as mitral valve elongation, crypts, markers of elevated LV systolic function, and abnormal apical trabeculation. Reverse curvature of the interventricular septum into the LV is a characteristic of G+LVH+ patients. We aimed to assess LV septal convexity into the LV in G+LVH-.