Solid−Liquid Equilibria in an l-Isoleucine + l-Norleucine + Water System

Solid−liquid equilibria in l-isoleucine (l-Ile) + l-norleucine (l-Nle) and water were measured at 293 K using the crystallization method. The l-Ile solubility in water is unaffected by small amounts of l-Nle. However, l-Ile solubility decreases rapidly with increased l-Nle. As for the solid phase, the formation of a solid solution of l-Ile and l-Nle was confirmed using synchrotron X-ray diffraction analysis.