Cryptococcal Meningitis and Intracranial Tuberculoma in a Patient with Waldenstrom's Macroglobulinemia Treated with Fludarabine

We report a patient with Waldenstrom's Macroglobulinemia who presented with cryptococcal meningitis followed by an intracranial tuberculoma during the 18 months period after termination of cytotoxic therapy with Fludarabine. Opportunistic infections due to intracellular organisms are extremely rare in the course of this malignancy and we review the predisposing factors of these infectious entities.