Alterations of lipid profile are a risk factor for venous thromboembolism and thrombotic complications

We studied a group of patients with thromboembolic disease, demographic data, thrombotic and classical cardiovascular risk factors, and thrombotic complications were collected. Lipid profile including total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides was established for all patients. Three hundred and thirty-nine patients and 295 controls were included in the study. The mean age of both groups was 53.3 (±16.4) years for patients and 57.0 (±17.4) for controls (p = 0.006). Patient and control groups were composed of 53.4% (n = 181) and 52.2% (n = 154) of men, respectively (p = 0.765). LDL-C > 180 mg/dL and TC > 220 mg/dL were associated with an increased risk of venous thromboembolism (VTE; OR: 7.76, 95% CI: 2.97–26.65, p   180 mg/dL (OR: 1.93, 95% CI: 1.03–3.58, p = 0.04) with recurrent events. We found a significant association between HDL-C   180 mg/dL (OR: 2.56, 95%CI: 1.34–4.83, p = 0.004) with PTS. Our study confirmed the association between dyslipidemia and VTE. In addition, alterations in the lipid profile were also related to a higher prevalence of thrombotic complications. Practical applications: A deeper understanding of the risk factors associated with VTE and its major complications, recurrence and post-thrombotic syndrome, allow us to identify earlier and more effectively those individuals with an increased risk of thrombosis, and therefore apply appropriate therapeutic and prophylactic measures in certain thrombotic risk situations.