The Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway

Yaguang Zhou,Yuanbo Wang,Xu Wang,Xin Tian,Shumiao Zhang,Fan-Yang,Hai-Tao Guo,Rong Fan,Na Feng,Min Jia,Xiaoming Gu,Yue-Min Wang,Juan Li,Jianming Pei

The Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway

2017

Yaguang Zhou
Yuanbo Wang
Xu Wang
Xin Tian
Shumiao Zhang
Fan-Yang
Hai-Tao Guo
Rong Fan
Na Feng
Min Jia
Xiaoming Gu
Yue-Min Wang
Juan Li
Jianming Pei

Background/Aims: In a previous study, we showed that κ-opioid receptor stimulation with the selective agonist U50,488H ameliorated hypoxic pulmonary hypertension

Keywords:

Autophagy
PI3K/AKT/mTOR pathway
Pulmonary hypertension
Hypoxia (medical)
AMPK
Opioid receptor
Agonist
Biology
Receptor
Biochemistry
Pharmacology
Apoptosis
Viability assay
Receptor antagonist

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