Clinical and Functional Outcome of Percutaneous Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy

Background: Percutaneous septal ablation is a therapeutic option for patients with obstructive hypertrophic cardiomyopathyrefractory to optimal medical therapy. However, results of initial persistence and long-term safety are still controversial.Objectives: The aim of this study was to report percutaneous alcohol septal ablation technique, clinical and functional outcome,cardiovascular events and its impact on long-term follow-up.Methods: A total of 23 patients were included in the study. Functional class (FC), left ventricular outflow tract gradient beforeand after the procedure and long-term cardiovascular events were evaluated.Results: Median follow-up was 52 months (IR 33-72). All patients were in FC III or IV prior to the procedure, under maximumtolerated medical therapy. The procedure was successful in 91% of cases, with 85% of patients currently in FC I and 15% inFC II. Baseline left ventricular outflow tract gradient decreased from 75 mmHg (95% CI 51-89) to 25 mmHg (95% CI 10-37)(p<0.003) and with Valsalva maneuver from 118 mmHg (95% CI 88-152) to 38 mmHg (IC 95% 16-69) (p<0.0002), persistingin the long-term follow-up. During hospitalization, two patients presented with complete atrioventricular block requiringpermanent pacemaker implantation. No cardiovascular deaths occurred during follow up.Conclusions: Alcohol septal ablation is a promising option for the treatment of a selected population with hypertrophicobstructive cardiomyopathy, generating sustained clinical and functional improvement with low incidence of events in thelong-term follow up.