Alkylsulfoxide heterocycles of 4-benzylpiperidine and use as selective antagonists of NMDA subtype.

A compound represented by the formula ** ** or stereoisomers or a pharmaceutically acceptable salt thereof, wherein R and r, independently selected from the group consisting of hydrogen, hydroxy, C1-C6 alkyl, halogen, nitro, cyano, carboxaldehyde aldehyde amine, C1-C6- carbonylmethyl, hydroxy C1-C6 alkyl, aminocarbonylmethyl, hydrazinocarbonylmethyl, acetamido, aryl selected from phenyl or naphthyl, aralkyl wherein alkyl and aryl is defined as above, amino, a C1-C6 halogenated, a C1-C6 alkyl amino group or a C1-C6 alkoxy; R??? R?? and are independently from the group consisting of hydrogen, hydroxy, C1-C6 alkyl, halogen, amino, a C1-C6 halogenated, an alkyl amino C1-C6 group or an alkoxy group C1 C6; X is hydrogen or hydroxy; Z is -CH2- n is 2 to 4; and Y is O, NH or S.