Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929: I. Producing strain, fermentation, isolation, and biological activities

New protein farnesyltransferase inhibitors, andrastins A-C, have been discovered in the cultured broth of Penidllium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3μM, respectively.