Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus

Abstract Eleven highly oxygenated meroterpenoids, named terreustoxins A−K, along with five known analogues, were isolated from the Antarctic fungus Aspergillus terreus . The structures and absolute configurations of these undescribed compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Terreustoxins A−D are the first examples of meroterpenoids with two ortho-hydroxy groups at C-6 and C-7 in the terretonins family. Terreustoxin C and terretonin inhibited the proliferation of Con A-induced murine T cells at the concentration of 10  μ M.