KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation
2011
KISS1R is dynamically recycled to the cell surface rather than degraded; KISS1R is degraded by the proteasome rather than the lysosome; and decreased degradation of the Arg386Pro mutant accounts for the prolonged responsiveness of this mutant to kisspeptin.
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