Enantiomer-Specific Bioaccumulation and Distribution of Chiral Pharmaceuticals in a Subtropical Marine Food Web

Abstract There is a growing concern about the occurrence of chiral pharmaceuticals in the aquatic environment. However, trophic transfer of pharmaceutical enantiomers in marine organisms is still largely unknown. This study assessed the bioaccumulation and spatial distribution of four frequently detected pharmaceuticals — atenolol, metoprolol, venlafaxine, and chloramphenicol, in a subtropical marine food web in Hong Kong waters. Twenty-four species were analyzed, including mollusks, crustaceans, and fishes. Special focus was placed in the chirality of the four analytes comprising ten different stereoisomers. Results showed that mean concentrations of individual pharmaceuticals ranged from