Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons.

Phosphodiesterase (PDE) activity in olfactory sensory neuron cilia is thought to be responsible for degrading odor-induced signaling, resulting in rapid response termination. However, disrupting the variety of PDE found only in cilia unexpectedly turns out not to result in a rapid response termination deficit. Only eliminating both cilia-localized and cell body–localized varieties of PDEs resulted in prolonged termination.