Detection and clinical significance of serum anti-nuclear antibodies in patients with hepatitis B virus infection

Objective To detect the serum anti-nuclear antibodies(ANA) and investigate its clinical significance in patients with hepatitis B virus(HBV) infection.Methods A total of 120 patients with HBV infection and 82 healthy subjects were enrolled,and indirect immuno-fluorescent assay(IIF) was used to detect the serum ANA.Results The positive rate of ANA in 120 patients with HBV infection(30.0%) was higher than that of healthy subjects(4.2%).ANA in patients with HBV infection was mainly depended on low titer(1∶ 100,58.3%).The ANA granular fluorescence(41.7%) was highest in the patients with HBV infection.Conclusions HBV infection can induce to produce a variety of low titer ANA,and may play a certain role in the diagnosis,differential diagnosis and treatment.The pathogenesis of HBV may have some relationship with autoimmune.