Whipple case presenting with cachexia

Whipple’s disease is a bacterial systemic inflammatory disease is caused by Tropheryma whipplei. Classic Whipple’s disease includes arthralgia, diarrhea, abdominal pain, and weight loss. The diagnosis is confirmed by Periodic Acid-Schiff (PAS) positive macrophages presented in small bowel biopsy. The treatment requires long-term antibiotic therapy and the disease could be fatal if not treated. Whipple’s disease should be considered in patients claiming from diarrhea, abdominal pain and malabsorption either most common seen causes are excluded. In this case report, we will present a fifty-four years old patient who presented with weight loss, arthralgia, and chronic diarrhea.