Abstract 287: What Is the Optimal Chest Compression Depth During Resuscitation from Out-of-Hospital Cardiac Arrest in Adult Patients?

Introduction: The 2010 AHA/ILCOR recommendations suggested an increase in CPR compression depth for adults, with a target >50 mm and no upper limit. This target is based upon limited evidence and, hence, we sought to determine the optimal compression depth range for adult patients. Methods: We studied emergency medical services treated OOHCA patients from the Resuscitation Outcomes Consortium ROC PRIMED clinical trial and Epistry - Cardiac Arrest database for whom electronic CPR compression depth data were available, from June 2007 to December 2010. We calculated anterior chest wall depression in millimeters for each minute of CPR. We controlled for 10 covariates including compression rate and calculated adjusted odds ratios for survival to hospital discharge, 24-hour survival, and any return of circulation (ROSC). Smoothing splines were used to explore the relationship between average compression depth and outcome for all patients as well as men and women separately. Results: We included 9,142 adult pati...