Research on ultrasonographic and hemodynamic changes of liver and spleen in patients with trichloroethylene medicamentous dermatitis

Objective To study the ultrasonographic and hemodynamic changes of liver and spleen in patients with trichloroethylene(TCE)medicamentous dermatitis and their clinical significance.Methods 50 patients(31 men and 19 women)with TCE medicamentous dermatitis in our hospital were observed with color Doppler system(General LOGIQ7).All patients were confirmed by Guangdong diagnosis group for occupational disease.The observed indexes included hepatic vein diameter(HVD)and Doppler waveform changes,portal vein diameter(PVD)and portal blood flow(PVF or PVQ),ultrasonic integrated backscatter(IBS)of liver,maximal diagonal of lobus hepatic,spleen thickness and longitudinal length(SPT,SPL),spleen vein diameter(SPVD),spleen vein blood flow(SPVF or SPVQ),maximum blood velocity of splenic vein(SPVx).50 persons(30 men and 20 women)without hepatic and viscera diseases and non-exposed to liver toxic materials were selected as the control.Results All indexes metioned above except HVD and SPVQ were significantly higher in patients with TCE medicamentous dermatitis than those of the control(P0.01).The values of HVD and SPVQ were lower than those of the control,the differences were significant(P0.01).Conclusion The changes of ultrasonography and hemodynamics for liver and spleen might be early existed.Doppler ultrasonography and hemodynamic test for liver and spleen vein might be used as a quantitative detection for TCE medicamentous.Ultrasonography can provide evidence for diagnose and therapy of TCE medicamentous,showing certain clinical value.The occurrence ratio of hepatic dysfunction with TCE medicamentous dermatitis was high and severe.Ultrasonography of abdomen especially portal vein blood flow has characteristic changes.The portal vein blood flow can be used as one of the indexes of liver function.