Correlativity between blood-stasis syndrome in cardiopathy and activity of fibrinolytic system.

Objective:To explore the pathologic mechanism of blood-stasis syndrome in cardiopathy(BSSC) and its different syndrome types from the activity of fi brinolytic system.Methods:72 cases with BSSC,20 cases with non-blood-stasis syndrome in cardiopathy(NBSSC) were observed at random,20 healthy cases as control.The levels of tissue-plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) in blood plasma were detected by ELISA.Results:①The level of t-PA in the group of BSSC was signifi cantly lower than that in the groups of healthy control and NBSSC(P0.01),and the levels of PAI-1 and PAI-1/t-PA were signifi cantly higher than those in the groups of healthy control and NBSSC(P0.01).②The level of t-PA in different syndrome type groups in patients with BSSC was signifi cantly lower than that in the healthy control group(P0.01),and the levels of PAI-1,PAI-1/t-PA were signif icantly higher than those in the healthy control group(P0.05 or P0.01).Conclusion:The decrease of the activity of fi brinolytic system was the important factor in the formation of BSSC.It was thought that the synthetic analysis of the levels of t-PA,PAI-1 and PAI-1/t-PA had some value for the diagnosis of BSSC.