Response: priming of human naive CD4+ T cells via CD5 costimulation requires IL-6 for optimal Th17 development

With interest we read the letter by Ayyoub and coworkers who compare the efficacy of Th17 differentiation from naive FOXP3+CD25+CD127− NTregs and conventional naive T cells.[1][1] We previously reported that compared with CD28, alternative costimulation via CD5 enhanced Th17 differentiation from