The Effect of Lidocaine on Liver Tissue Lipid Peroxide Levels in Septic Rat Model

Sepsis is characterized with increased free oxygen metabolites that lead to multiple organ dysfunction. The aim of this study was to evaluate the effect of lidocaine on oxidative/antioxidant system in rats with sterile and sepsis-induced liver injury. 44 Swiss-Albino male rats (weighed 200-250 g) were included to this study. Rats were classified into four groups. Group 1: Saline infused sham control (n=12), Group 2: Septic (n=12), Group 3: Lidocaine infused sham control (n=12), Group 4: Lidocaine infused septic (n=12). Subcutaneous saline or lidocaine treatment was performed in 10 minutes after surgical operation and continued for 24 hours. Liver tissue samples were dissected. Tissue malondialdehyde, nitric oxide and myeloperoxidase levels were determined by spectrophotometric methods. Liver tissue levels of malondialdehyde, nitric oxide and myeloperoxidase levels of Group 2 were significantly higher compared to Group 1 (p=<0.001, p=0.001 and p=0.002, respectively). Liver tissue levels of malondialdehyde, nitric oxide and myeloperoxidase levels of Group 3 were significantly lower than Group 1 (p=<0.001, p=0.008 and p=0.018, respectively). Liver tissue levels of malondialdehyde, nitric oxide and myeloperoxidase levels of Group 4 were significantly lower than Group 2 (p=<0.001, p=0.001 and p=0.02, respectively). According to this study's results, lidocaine has a positive effect on antioxidant system by diminishing the lipid peroxidation in rats with sterile and sepsis induced liver injury.