Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3).

Daniel D. Murray,Abdel Babiker,Jason V. Baker,Christina E. Barkauskas,Samuel M. Brown,Christina C. Chang,Victoria J. Davey,Annetine C. Gelijns,Adit A. Ginde,Birgit Grund,Elizabeth S. Higgs,Fleur Hudson,Virginia L. Kan,H. Clifford Lane,Thomas A. Murray,Roger Paredes,Mahesh K. B. Parmar,Sarah Pett,Andrew N. Phillips,Mark N. Polizzotto,Cavan S. Reilly,Uriel Sandkovsky,Shweta Sharma,Marc Teitelbaum,B. Taylor Thompson,Barnaby Edward Young,James D. Neaton,Jens D. Lundgren

Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3).

2021

Background/aimsSafe and effective therapies for COVID-19 are urgently needed. In order to meet this need, the Accelerating COVID-19 Therapeutic Interventions and Vaccines public–private partnership...

Keywords:

2019 20 coronavirus outbreak
protocol
Intensive care medicine
Coronavirus disease 2019
Medicine
severe acute respiratory syndrome coronavirus 2
multi stage

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