Truncation of 3′ CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma

Fumiyo Maekawa,Chiyuki Kishimori,Miho Nakagawa,Kayo Takeoka,Katsuhiro Fukutsuka,Masahiko Hayashida,Futoshi Iioka,Masakazu Fujimoto,Kengo Takeuchi,Hirokazu Nakamine,Hitoshi Ohno

Truncation of 3′ CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma

2021

Fumiyo Maekawa
Chiyuki Kishimori
Miho Nakagawa
Kayo Takeoka
Katsuhiro Fukutsuka
Masahiko Hayashida
Futoshi Iioka
Masakazu Fujimoto
Kengo Takeuchi
Hirokazu Nakamine
Hitoshi Ohno

t(11;22)(q13;q11)/CCND1-IGL resulted in truncation of the CCND1 3′ coding sequences in a case of blastoid variant mantle cell lymphoma. The translocation generated CCND1 with a C-terminal alteration, leading to negative CCND1 immunohistochemistry by SP4 monoclonal antibody.

Keywords:

Immunohistochemistry
Mantle cell lymphoma
Blastoid
Truncation
Cyclin D1
Pathology
Chemistry

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