Kimura’s Disease with Marked Proliferation of HLA-DR+CD4+ T Cells in the Skin, Lymph Node and Peripheral Blood

A 41-year-old female had atopic dermatitis-like skin lesions since the age of 21, and for the past 6 years many skin tumors developed on the body, lower extremities and other areas. The histological picture of the tumor, eosinophilia and high IgE in the peripheral blood were consistent with a diagnosis of Kimura’s disease. Although the tumors were markedly reduced by oral prednisolone administration, thereafter papules appeared disseminated over the body with swelling of superficial lymph nodes. Immunohistochemical examination indicated marked proliferation of HLA-DR+CD4+ T cells in the skin and lymph nodes, and two-color flow cytometry confirmed it in the lymph nodes and peripheral blood.