THU0428 Psoriasis Arthritis Is Associated with Periarticular Bone Loss of The Metacarpals

Background The BoneXpert is a new Digital X-ray Radiogrammetry method measures the cortical bone thickness of the metacarpals. Objectives The aim of this study was to quantify cortical bone loss in patients with Psoriasis Arthritis (PsA) and to compare these findings with the PsA modified van der Heijde Sharp Score. Methods The study includes 104 PsA patients. The BoneXpert method was used to measure the Metacarpal Index (MCI BX ) at the metacarpal bones (II to IV). Additionally, the T-Score of the MCI (T-Score MCI ) was calculated. Radiographic severity was evaluated by the PsA modified van der Heijde Sharp Score (Joint Space Narrowing Score and Erosion Score). Results For the total PsA study cohort the T-Score MCI was significantly reduced with -1.289 ± 1.313 SD. The MCI presented a negative correlation to the Joint Space Narrowing Score (r = -0.558; p BX was quantified. The highest reduction was observed for the MCI BX with -28.5% (p Conclusions Patients with PsA presented also periarticular demineralisation and severity dependent bone loss as measured by the BX using the MCI BX . The BX-parameters seem to function as surrogate marker of radiographic progression in PsA and potentially differentiate between different stages of disease manifestation affecting bone structures. Disclosure of Interest None declared