Glycocalyx injury in adults with nephrotic syndrome: Association with endothelial function.
2015
Abstract Background Glomerulopathy is a group of diseases that affect mainly young adults. Endothelial dysfunction, atherosclerosis, and increased cardiac mortality can complicate the evolution of such patients. However, there is no study evaluating endothelial glycocalyx in this pathology. Methods This cross-sectional study included 49 patients with untreated primary nephrotic syndrome that were otherwise healthy. In addition to routine laboratory measurements, syndecan-1, intercellular adhesion molecule-1 (ICAM-1), and e-selectin were measured. Moreover, flow-mediated dilation (FMD) was used as the main endothelial function surrogate. Results Of the 49 patients with nephrotic syndrome, 25 (51.0%) were females. The mean age of patients was 39.0 ± 12.1 y. FMD was reduced in nephrotic patients in comparison with controls (3.7 ± 1.7 vs. 6.6 ± 1.1%, p Conclusions We demonstrated that syndecan-1, a marker of endothelial glycocalyx damage, is increased in patients with nephrotic syndrome and near-normal renal function. Moreover, we determined its association with nephrotic syndrome features and suggest it can have a role in the endothelial dysfunction of these patients.
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