Endowing Human Adenovirus Serotype 5 Vectors with Fiber Domains of Species B Greatly Enhances Gene Transfer into Human Mesenchymal Stem Cells

Shoshan Knaän-Shanzer,Marloes J.M. van de Watering,Ietje van der Velde,Manuel A.F.V. Gonçalves,Dinko Valerio,Antoine A. F. de Vries

Endowing Human Adenovirus Serotype 5 Vectors with Fiber Domains of Species B Greatly Enhances Gene Transfer into Human Mesenchymal Stem Cells

2005

Shoshan Knaän-Shanzer
Marloes J.M. van de Watering
Ietje van der Velde
Manuel A.F.V. Gonçalves
Dinko Valerio
Antoine A. F. de Vries

Bone marrow–derived human mesenchymal stem cells (hMSCs) lack the Coxsackie-adenovirus (Ad) receptor and thus are poorly transduced by vectors based on human Ad

Keywords:

Molecular biology
Cell biology
CD46
Mesenchymal stem cell
Adenovirus serotype
Gene
Biology
Viral vector
Virology
Receptor
gene transfer

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