Interstitial Disease of Autosomal Dominant Polycystic Kidney Disease
2014
Autosomal dominant polycystic kidney disease is a common single-gene genetic disease. It is one of the most important causes of end-stage renal failure. Its incidence is about 1/1000-1/400, ac- counting for about 10% of end-stage renal disease etiology. There are no effective drugs currently. In recent years, domestic and oversea researchers have conducted a lot of studies and discussions related to the pathogenesis, diagnosis and treatment, focused on the cyst development and secre- tion of cyst fluid secretion. But there is little research on renal interstitial disease, including in- terstitial inflammation and fibrosis. In this review, we mainly discuss the pathogenesis of ADPKD and effectives of interstitial disease in ADPKD.
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