Phenolic aralkylamines, monohydric alcohols, monocarbaldehydes, monoketones and monocarboxylic acids

Publisher Summary This chapter focuses on phenolic aralkylamines. The synthesis of aminoalkylphenols using the Mannich reaction involves many factors: the degree of ring substitution, phenol reactivity, pH, the Mannich reagent, the steric size of the amine component and whether it is primary or secondary. The chapter also discusses hydroxyaryl alcohols with examples and chemical formulae. The various methods of formylating aromatic rings have been reviewed. The the antioxidant property of dehydrozingerone and its analogs is examined in the ferric–ascorbate induced lipid peroxidation model in fat brain homogenate. Also the enzymatic formation of p-hydroxybenzoic acid from p-coumaric acid has been detected in cell free extracts of Litospermum erythrorhizon cell cultures. The results suggest that the reaction mechanism is non-oxidative. The oxidative decarboxylation of 3, 4-dihydroxymandelic acid to 3, 4-dihydroxy-benzaldehyde are also reviewed.