A kind of detect the method for organic solvent residual in dapoxetine

The present invention relates to and a kind of detect the method for organic solvent residual in dapoxetine, the method simultaneously detecting methanol in dapoxetine, ethanol, isopropanol, ether, normal hexane, ethyl acetate, oxolane residual particularly with gas chromatogram. Wherein, adopt external standard method to detect 7 kinds of Determination of Residual Organic Solvents in dapoxetine simultaneously, does is chromatographic condition: chromatographic column Agilent? DB-1301(30m × 0.32mm × 0.25 μm), column temperature 180 DEG C, injector temperature 200 DEG C, detects temperature 250 DEG C, carrier gas N 2 , split ratio 10:1, adopt headspace injection method, equilibration time 30min, equilibrium temperature 80 DEG C. Adopting gas chromatography to detect methanol in dapoxetine, ethanol, isopropanol, ether, normal hexane, ethyl acetate, content of tetrahydrofuran, highly sensitive, reproducible, degree of accuracy is high simultaneously. The inventive method is adapted to detect in dapoxetine 7 kinds of organic solvent residuals.