Post hoc assessment of relationship between coronary stenosis, ECG and ventricular function in patients with heart disease.

Cardiovascular diseases including cardiac arrhythmias lead to fatal events in patients with coronary artery disease, however clinical associations from echocardiography, electrocardiography (ECG) and biomarkers remain unknown. We sought to identify the factors that may be related to elevated QRS intervals in patients with risk for coronary artery disease. In this study, we performed analysis of clinical data from 503 patients and divided into two groups, i.e., patients with either 50% coronary artery stenosis. We further examined patients with elevated ECG parameters such as QRS>100ms and QTc>440ms. Patients with >50% coronary artery stenosis exhibited significant increases in age, triglycerides, and troponin levels. Further, ECG parameters demonstrated increased QRS and QTc durations, while echocardiographic parameters highlighted a decreased in ejection fraction (EF) and fractional shortening (FS). Patients with QTc>440ms exhibited increased Brain natriuretic peptide and Creatinine levels with a decrease in eGFR clearance rates. Patients with QRS>100ms had greater left ventricular (LV) mass, LV internal diameter in systole and diastole. Multimodal logistic regression showed significant relation between QTc, age and creatinine. These findings suggest that patients with significant coronary stenosis may have lower EF and FS with prolonged QRS intervals demonstrating greater risk for arrhythmic events.