glabrata infection with L-743,872. Treatment of murine Candida krusei or Candida

, are innately resistant tofluconazole, both in vitro and clinically (2, 5, 8, 9, 11, 13).Among the potential alternative drugs under development arethe pneumocandins, which act by blocking 1-3-b-glucan syn-thase, thus inhibiting cell wall synthesis (3, 6). This is a targetnot affected by fluconazole, so pneumocandins may be effectivein fluconazole-resistant