Пролиферативная активность, степень злокачественности и прогноз при карциноидных опухолях легких

The purpose of this study was to analyze expression of argyrophilic nucleolar proteins B23/nucleophosmin and C23/nucleolin, to determine Ki-67 score characterizing mitotic cycle rate and the number of proliferating cells respectively and to evaluate the role of these parameters in assessment of proliferative activity, grade and prognosis for pulmonary carcinoid. A total of 18 carcinoids (13 typical and 5 atypical) were studied. Tumor growth rate and grade were found to correlate with ratio of the number of proliferating cells and rate of cell proliferation. B23/nucleophosmin and C23/nucleolin overexpression was associated with enhanced metastasis andmightplayasignificantroleinapoptosis inhibitionintumorcellsasabasisfortumorprogression. Difference in expression of Ag-NOR proteins may be a useful additional marker for differentiation between typical and atypical pulmonary carcinoids.