The Triple Threat of Recurrence after Breast Conserving Therapy: Race, Receptor Status and Age.

Purpose The purpose of this study is to evaluate the impact of race, receptor status, and age on recurrence in patients undergoing breast conserving therapy (BCT). Methods The study population consisted of 510 primary invasive female breast cancer patients (excluding Stage IV), who resided in Fulton-Dekalb counties, in Atlanta, GA. These patients were diagnosed in 2003-2004 and treated within the Emory University Affiliated Hospitals. Data was obtained from the SEER cancer registry and augmented with medical record abstraction. Median follow-up was 3.5 and 4.4 years for recurrence and survival, respectively. Breast tumors were categorized as either triple negative (TN), which were estrogen, progesterone, and Her2-neu receptor negative tumors, versus (vs) non-TN, all other possible iterations. Women were evaluated for recurrence and death by TN status, race (African American (AA) vs Caucasian (C)), age, grade, tumor size, nodal status, socioeconomic status (SES), and receipt of chemotherapy. Both recurrence and survival were evaluated using chi-square, fisher exact, and cox regression analyses, p ≤ 0.05 significance. Results Of the 510 women, 193 received BCT. Of the 193, 92% completed radiation therapy and 45% received chemotherapy. Of the 184 women with known recurrence status, 11 recurred locally, 11 distantly, and none regionally. Compared to patients with non-TN tumors, TN patients had significantly higher local (13% vs 5%) and distant (16% vs 4%) recurrence rates. AA women had non-significant higher local recurrence than C women (7% vs 4%) and a higher distant recurrence rate (8% vs 3%). Finally, compared to women ≥50 years old, women age Conclusion We observed that there was a significant increase in local and distant metastatic recurrence rates after BCT among patients diagnosed with TN breast cancers, AA women, and women Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6045.