Synthetic method of 2-(1-hydro-4-tetrazole)-4'-methyl diphenyl

The invention discloses a synthetic method of 2-(1-hydro-4-tetrazole)-4'-methyl diphenyl. The method comprises the following steps: by taking 2-carboxyl-4'-methyl diphenyl as a raw material, reacting with benzene sulfonamide under a high-temperature melting condition; subsequently adding ammonium acetate and reacting again at the high-temperature melting condition to prepare 2-amidino-4'-methyl diphenyl; afterwards allowing 2-amidino-4'-methyl diphenyl and hydrazine hydrate to have a substitution reaction to prepare 4'-methyl-[1,1'-diphenyl]-2-formamide hydrazide; finally allowing 4'-methyl-[1,1'-diphenyl]-2-formamide hydrazide and sodium nitrite to have a cyclization reaction to prepare 2-(1-hydro-4-tetrazole)-4'-methyl diphenyl. The synthetic method disclosed by the invention is mild in reaction condition, simple and convenient to operate and suitable for industrial production; carboxylic acid is creatively used for replacing nitrile as a raw material; the use of a highly-toxic and easily-explosive reagent is avoided, such as a reagent like sodium azide; the raw materials are easy to obtain and safe; convenience is provided for production management; the cost is relatively low; pollution of three wastes is reduced.