Investigating the Ability of Spatial Frequency Domain Technology in Tissue Differentiation

in biomedical and pharmaceutical international markets, there is a huge ambition to use the optical imaging techniques in biological screening and pathogen identification to diagnose abnormal or cancerous cells. Spatial frequency domain imaging is a recent, non-invasive and wide field optical imaging technology developed to quantify a spatial visualization of the tissue absorption and scattering characteristics utilizing the tissue diffuse reflectance dependency on the spatial frequency. In this work, we reveal the capability of Spatial Frequency Domain Imaging method to differentiate biological tissues according to their chromophores concentrations. For this purpose, normal and coagulated samples of chicken liver were experimentally examined with the optical system at different spatial frequency. The presented results showed a quite difference in the reflectance profile and optical properties for each tissue sample providing the ability of implementing the presented technique in medical analysis and identifications.