Toxicity and Apoptosis Related Effects of Benzimidazo [3,2-α] Quinolinium Salts Upon Human Lymphoma Cells

Christian Velez,Jessica Soto,Karoline Ríos,Luz Silva,Wigberto J. Hernandez,Luis Rivera,Ana I. Ortiz-Colón,Osvaldo Cox,Beatriz Zayas

Toxicity and Apoptosis Related Effects of Benzimidazo [3,2-α] Quinolinium Salts Upon Human Lymphoma Cells

2017

Christian Velez
Jessica Soto
Karoline Ríos
Luz Silva
Wigberto J. Hernandez
Luis Rivera
Ana I. Ortiz-Colón
Osvaldo Cox
Beatriz Zayas

Objectives: The present study evaluates novel cationic quinoline derivatives known as benzimidazo[3,2-a]quinolinium salts (BQS) named NBQ-48 and ABQ-48 that have structural similarities to known anti-cancer substances such as ellipticine and berberine.

Keywords:

Chemistry
Diffuse large B-cell lymphoma
Lymphoma
Apoptosis-inducing factor
Apoptosis
Biochemistry
Cancer research
Toxicity
Immunology
Programmed cell death
Mechanism of action
Cell cycle checkpoint
Caspase
Caspase 3

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